UK Research and Innovation Jobs as Octopus facility Operations and imaging protein function, DNA damage and the mTOR pathway Industrial Placement at Didcot,England,UnitedKingdom 2022

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This Job Listing is about UK Research and Innovation in Didcot,England,UnitedKingdom 2022 posted on

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<!--> Science and Technology Facilities Council Salary: £20,129 per annum Hours: Full time Contract Type: Fixed Term (12 months) Location: Science and Technology Facilities Council, Rutherford Appleton Laboratory Harwell, Oxfordshire The Lasers for Science Facility (LSF) at the Rutherford Appleton Laboratory develops and provides access to advanced laser techniques for the scientific community. Working as a member of the Imaging team in the Research Complex , this placement will be involved in developing aspects of the imaging facilities, known as OCTOPUS (Optics Combined To OutPut Unique Solutions). The OCTOPUS combines super resolution, confocal and single molecule microscopy (multicolour and multiphoton), fluorescence lifetime imaging (FLIM), fluorescence resonance energy transfer (FRET), and image correlation spectroscopy (ICS) to investigate the conformation and interactions of molecules in cells. The science programmes of Octopus include the use of FLIM for the investigation of complexes used for medical imaging (collaboration with Oxford, Bath, Sheffield and Manchester Universities). We also use single molecule techniques to study the sophisticated signalling pathways of cells (STFC, King’s College London, Oxford Brookes, and Cambridge), using FRET/FLIM and optical trapping to study the secretory pathways of plants (Oxford Brookes, Bristol University and STFC), and using confocal microscopy to study DNA damage and repair (STFC and Oxford). This successful candidate will very much work part of a team, assisting researchers from universities and industry and will be encouraged to gain hands-on experience of imaging equipment, laser systems and diagnostic equipment, cell and molecular biology Full training will be given in all aspects of general laboratory work and the operation of specialised equipment. Do you have a background in life sciences? A curiosity about computing, optics or electronics would be an advantage but are not essential, as full training will be given as needed, and the exact project selected will be chosen to suit the experience of the student. Overview of our industrial placement scheme STFC’s exceptionally diverse range of placements allow you to work alongside world leading engineers, scientists and technicians in highly collaborative environments. Whichever you choose, you’ll become a critical member of the team in which you will be exposed to exciting projects and challenges from the beginning. You’ll be supported every step of the way by our dedicated Early Careers Team who will also ensure you benefit from a range of personal development opportunities. STFC offers a benefits package crafted to provide an excellent work/life balance including 30 days’ annual leave, 10.5 public and privilege days, Christmas closure and flexible working hours. For more information on our full list of benefits, please visit here. Summary Of Responsibilities During the 12-month placement, the successful student will be encouraged to carry out projects to develop and extend the capabilities of OCTOPUS. In particular, the work will be directed towards the integration new microscopic techniques to a range of end station. This will be applied to novel biological questions such as how cells deploy proteins for DNA damage and repair and via the mTOR pathway. Projects will include:

  • Working with the two confocal microscope systems (multiphoton and multicolour) to provide a common user interface, allowing the easy exchange of samples between microscopes
  • Developing a time resolved anisotropy imaging technique
  • Combining confocal and single molecule techniques to allow the collection of complementary information on intracellular location, molecular interactions and conformation
  • Assisting with developing entangled photon imaging
In order to apply for this placement, we are looking for the following: Essential
  • Currently enrolled on an undergraduate degree course
  • Be required or have requested to take a placement year
  • Have the right to live and work in the UK for the duration of the placement
  • 3 A’Levels- scientific, minimum 2 years higher education (pre degree)
  • Laboratory experience
  • Working with biochemical and/or chemical spectroscopy and /or instrumentation
  • Ability to perform literature search to assess related work related to activities within the group
  • Good level of written communication
  • Good communication skills
  • Laboratory experience working with biochemical and/or chemical spectroscopy and /or instrumentation
  • Ability to discuss work related to activities within the group
  • An interest in computing, optics or electronics
Part of our application process involves submitting your CV and a cover letter. Your cover letter should address your suitability for the opportunity based on how you meet each essential criteria stated in this advert. You are advised to submit your application as soon as possible as we reserve the right to close this vacancy once we have received sufficient applications. About The Science And Technology Facilities Council (STFC) As one of Europe’s largest research organisations, we ask the biggest questions in the universe to find answers that change the world around us. We seek understanding. We’re proud of the impact we make. And we’re committed to helping build a globally competitive, knowledge-based UK economy. Being part of all this means contributing to work that pushes boundaries and creates possibilities. You’ll work with, and learn from, true experts. Whatever your role, you’ll be free to question, and encouraged to share ideas. And, in a positive and supportive culture, you’ll discover just what a difference you can make when you’re equipped and inspired to excel. We’re a place where curious minds thrive. Not bound by profit, we explore ideas that others don’t, ask questions that others won’t, and discover answers that others are not equipped to find. And, alongside Mars landings and black holes, we also explore diverse, international projects in everything from science and engineering to computing and technology. Whether it’s at the cutting edge or behind the scenes, our work is intellectually challenging. It’s very often ground-breaking. And it’s endlessly, irresistibly fascinating. For more information about STFC please visit You can also visit our careers site About UK Research Innovation (UKRI) UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world’s most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI. How We Support EDI In The Workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit ‘How we support EDI in the workforce’. Disability Confident Employer As users of the disability confident scheme, we guarantee to interview all disabled applicants who meet the minimum criteria for the vacancy/ies. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. How To Apply Online applications only preferred for this role. Please submit a CV and covering letter which clearly outlines how you fulfil the criteria specified along with your motivation for UKRI and the role. Ensure that the job reference number is included in the filename description of each document uploaded. Note that failure to address the above criteria or submit an application without a covering letter may result in the application not being considered. Assessment will only be based upon the content of your submitted covering letter and CV and not the ‘experience’ section of the application. UKRI seeks to ensure it creates and maintains a system of openness, fairness and inclusion – a collaborative, trusted environment, which is attractive to and accessible to everyone who is interested in developing their career with us.-->

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